To me, it just depends on whether artist's body of work is influenced by artist's personal views or actions. Because you can be an a-hole in real life, and Mr. Magic in whatever is what you do (drawing, writing, acting, directing). In fact, when I look at directing for instance, James Cameron or Michael Bay are a-hole directors to me, but hey, one made Aliens, Abyss, Avatar, the other made Transformers series, earning piles of money in the process. And old Hollywood directors were much cruel toward actors and crew. But should we hate John Ford's She Wore Yellow Ribbon? I don't think so. Someone mentioned HPL. I admit I haven't got his views initially, only when I read his biography. In Shadow Over Innsmouth, fishmen were scary because I thought of them as any malicious monsters you could find. Needless to say, HPL views were typical for 1920s. Okay, now I am straying off the subject here. Back on point, I believe reader's (or viewers) should have a little responsibility to what they chose as an object of consummation. What I do, for instance, before I read something new that interests me, is to read about the work, the artist so I could determine if I actually will enjoy it. I never read Cerebus, neither now I will. On the other hand, I loved Ender's Game, even though Orson Scott Card doesn't like two uncles in intimate situations. But to find something that just a little reeks on homophobia in Ender's Game is like a searching for needle in haystack.
Finally, like someone said, we all draw our (personal) lines. So, what matters to me, might not matter to other and vice-versa.