I know what you mean, they can seem a bit one-note. Though, I thought Angelic did a good job of fleshing out Pa (even if it’s an alternate universe), and reckon there’s plenty material/suggested history for a good writer to work with.
Tell the stories from Mean’s perspective. A pre-op Mean as main protagonist would allow the others to remain simplistic, as they’re juxtaposed against a sympathetic reader-analogue, who intentionally doesn’t fit in. Almost like ‘Harry Potter vs the Dursleys’ on steroids, except we know Mean is doomed to an unhappy ending.
Have the rest of the gang as antagonists, but maybe bring in Mama Mojo’s inbred clan from Missionary Man as the villains. It was inferred that the Angels had encountered them at some point and more than met their match.