I often forget to check the Spoilers threads, and then I miss out on fascinating discussions like this one!
On the Beano, I met one of the top Beano bods at a book fair and he said there was a lot of discussion about updating the Bash St Kids, and their biggest sticking point was that they desperately wanted to get in some ethnic diversity, but couldn't work out how to do it without being offensive, e.g. if Fatyy is now Sikh, does that mean all Sikhs are fat? Or all Hindus are spotty? If Sid n Toots become Muslim, what style of dress would they wear - since it has to be the same every episode? Can you make a character Jewish without falling into some hideous facial stereotyping?
Changing the names seems like a fair place to start. I appreciate the call to rename Plug and Toots - but I remember having to explain to my kids what those names actually meant - any original concept of 'ugly' or 'girl' seems to have been long forgotten - they just took them as nicknames.
On the general topic of 2000AD as subversive, there's one thing I do still wish the Regened episodes would try, and that's to be more subversive with the art. Not that the artists aren't doing a great job, more that they don't seem to have the license - or perhaps the instinct - to draw things that are a) unpleasant to look at and b) things that teachers would still say 'eeer - you shouldn't be looking at that, you're not old enough'. Which includes gorey violence, but also sex and body horror and who knows what. I admit there's a huge bit of nostalgia in me saying this, the child who remembers lavishly copying that picture of Nostradamus's rotting face onto the inside of my school file.

I don't think Matt Smith gets enough credit for quietly allowing explicit nudity, swearing and sex (and talking demon-possessed dildoes) to creep into the Prog and Meg. Sure, it's always better when the stories are good, but that's the challenge of commercial art generally.
On the other hand, as someone else pointed out, if kids want to see horrible things (and they often do), then the Internet is their friend. Maybe it's better if a comic can be a safer place to retreat to than that...